Nanotechnology regulation of tumor microenvironment and new nano drugs

The key scientific problem to be solved is how to develop nano drugs to regulate the tumor microenvironment according to the characteristics of the tumor's special microenvironment, and how to clarify how nano drugs can more effectively regulate the tumor microenvironment and inhibit the development of tumors. The key technical problems to be solved are 1) new nano carriers and key preparation technologies of nano drugs to regulate the tumor microenvironment 2) analyzing the absorption, transport Innovative methods for metabolic and safety evaluation. Research objectives and expected results clarify the mechanism of nano drugs regulating tumor microenvironment and inhibiting tumor development, make breakthroughs in key preparation technologies of nano drugs, make breakthroughs in clinical transformation, and obtain 3-4 kinds of drugs for liver cancer Clinical approval documents or new drug certificates of nano drugs based on tumor microenvironment regulation or tumor comprehensive treatment for pancreatic cancer and other treatments Develop 4-6 kinds of nanotechnology new strategies for regulating tumor microenvironment Develop 3-5 kinds of innovative methods for analyzing the absorption, transport, metabolism and safety evaluation of nano drugs in cells and living bodies and obtain important original achievements, and publish more than 100 papers in high-level journals such as Science or Nature series, Apply for 20-30 invention patents and strive to win national awards. The project plans to develop advanced nano drug preparation technology and new nano technology strategy for regulating tumor microenvironment through precision self-assembly, micro nano processing, nano property control, multivalent delivery and other technical means. At the same time, the project plans to regulate tumor microenvironment with nano drugs through precision self-assembly, micro nano processing, nano property control, multivalent delivery and other technical means, At the same time, on the basis of the research on the mechanism of nano drugs regulating the tumor microenvironment, combined with the research on innovative methods of nano drugs' transport and metabolism in the tumor microenvironment, the joint treatment strategies such as nano drugs and immune microenvironment intervention are implemented to achieve the remodeling of tumor extracellular matrix, the regulation of cell internal signal and the regulation of cell external signal, Intervention of tumor immune microenvironment, and implementation of tumor stem cell targeting, so as to achieve the overall goal of project development of nano drugs and clinical transformation based on tumor microenvironment regulation.