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Design and development of advanced intelligent MEMS sensor system
Education/Training
At present, the project team relies on the good scientific research environment of the provincial key university, the National Defense Science and Technology Industry Bureau and the Hebei Provincial University of Science and Technology, the master's degree in electrical engineering, detection technology and automation device, the provincial key discipline of detection technology and automation device, the AVIC General Aviation Industry Key Engineering Laboratory and the Hebei Production Process Automation Engineering Technology Research Center, It has a complete electric drive experimental test platform, high-performance digital oscilloscope and computer-controlled experimental equipment, and has the ability to independently develop corresponding equipment. The team is neatly staffed, and the background covers the fields of electrical, control, measurement and control, all of which ensure the smooth completion of the research project. (1) The scale of the scientific research team needs to be expanded. It needs to cultivate and introduce high-level talents, actively learn from the experience and foundation of partners, and strengthen the research strength and accumulation of the team in this discipline; (2) The influence of research results is not high enough. The level of published papers needs to be continuously improved, and the independent intellectual property rights need to be continuously enhanced. (1) Further refine the research direction of the discipline, and take the research of the core application problems in the direction of new MEMS sensors as the guidance. Strengthen academic exchanges, encourage teachers to participate in international academic conferences and study abroad in relevant disciplines, or carry out cooperative research in the field of teaching and research with foreign research institutions. (2) Strengthen the curriculum construction of graduate students, and hire as many domestic and foreign experts and scholars as possible to offer cutting-edge theoretical courses. Encourage graduate students to actively participate in important domestic academic conferences. Further deepen the reform of talent training mode and constantly improve the quality of graduate talent training. (3) Based on the project, the research results were summarized, and more than 10 high-level papers were published in domestic and foreign academic journals, including 3 in SCI and 3 in EI; Participate in international academic conferences to exchange achievements and publish more than 3 papers; We have made breakthroughs in sensor modeling, motor structure design and control, and applied for more than 2 invention patents; On this basis, 3 master students will be trained. The School of Electrical Engineering of the University of Science and Technology of China now has a master's degree authorization in the first-level discipline of control science and engineering, and the second-level discipline of electrical machinery and electrical appliances. There are two engineering master's degree awarding fields of control engineering and electrical engineering. Detection technology and automation devices are national defense characteristic disciplines. Our research team has published more than 120 papers (including 30 SCI and 40 EI) and 3 monographs; 7 invention patents were obtained; Cultivate 23 postgraduate students; At the same time, relying on the projects of the National Natural Science Foundation, the Provincial Natural Science Foundation and the Provincial Department of Education, and facing the characteristics of the province's scientific and technological development, it has gradually realized the transformation from academic research and exploration to practical application, and has achieved certain results in industrial transformation. We carried out 12 projects and introduced more than 2.3 million yuan of funds.
Britain
2023-03-12
Clinical application of combined monitoring of cfDNA and CTC in the treatment of lung cancer
Other areas
1. It has a biological laboratory and a PCR laboratory 2. It has carried out a project of circulating tumor cells (CTC) 3. It has experienced, skilled and qualified technicians 1. It has established a prediction model for evaluating the therapeutic effect of two detection methods of CTC and cfDNA in patients with different stages of lung cancer; 2 Establish standardized test procedures and result interpretation standards. Through the detection of CTC and cfDNA, evaluate the value of the two detection methods to monitor the treatment of lung cancer alone and jointly: 1) clarify the correlation between the detection of CTC and cfDNA and the treatment effect of lung cancer, and establish a prediction model; 2) Published 1-2 SCI papers. The follow-up results will continue to apply for the project as a preliminary basis. The detection of cell free DNA fragments (cfDNA) is a new and fast developing "liquid biopsy" technology in recent years. The study found that the abnormal increase of cfDNA in plasma and serum of cancer patients [1] suggests that cfDNA is related to tumor and may become a biomarker for evaluating prognosis and monitoring curative effect [2]. Up to now, cfDNA has been found to have characteristic gene changes in colorectal cancer, pancreatic cancer, lung cancer and other tumors, including point mutation, microsatellite instability, DNA hypermethylation, loss of heterozygotes, etc. [3]. Many studies have shown that the gene changes of cfDNA are highly consistent with those of primary tumor and circulating tumor cells (CTC) [4,5]. The detection of CTC or circulating tumor cell DNA (ctDNA) cell-free DNA fragments (cfDNA) is a new and rapidly developing "liquid biopsy" technology in recent years. The study found that the abnormal increase of cfDNA in plasma and serum of cancer patients [1] suggests that cfDNA is related to tumor and may become a biomarker for evaluating prognosis and monitoring curative effect [2]. Up to now, cfDNA has been found to have characteristic gene changes in colorectal cancer, pancreatic cancer, lung cancer and other tumors, including point mutation, microsatellite instability, DNA hypermethylation, loss of heterozygotes, etc. [3]. Many studies have shown that the gene changes of cfDNA are highly consistent with those of primary tumor and circulating tumor cells (CTC) [4,5]. CTC or circulating tumor cell DNA (ctDNA) can be used as a new biomarker for tumor diagnosis, treatment and prognosis evaluation [6], but its content in patients' peripheral blood is low, and it is difficult to extract and identify. Because of its complex operation, high cost and long monitoring cycle, its practical application in clinical treatment is limited [7]. Previous data showed that there was a strong positive correlation between cfDNA and ctDNA content [8]. Therefore, we can indirectly monitor the response of tumor to treatment by detecting the level of cfDNA. In addition, normal tissues or cells will also undergo apoptosis or necrosis after being exposed to radiation, and a large amount of cfDNA will be released in a short period of time. The amount of change can indicate the risk of radiation damage [9]. How to detect the change of cfDNA content in blood with high sensitivity, accuracy, speed, convenience and efficiency is the key to develop the clinical application of this "liquid biopsy technology". Our cooperative research unit has developed a set of nucleic acid signal amplification technology (SuperbDNATM), which indirectly reflects the overall level of cfDNA by detecting the content of free Alu sequence in blood. Alu sequence is a highly expressed repetitive sequence, accounting for about 10% of the genome [10], and stably exists in the whole blood [11]. Its expression has a strong correlation with the level of total cfDNA [12]. This technology platform has a sensitivity of 91.7% and a specificity of 88.6% [13,14] for quantifying cfDNA, and has obtained a US global patent (patent number US 2012/0003625 A1). This technology platform is characterized by the use of modified Branched DNA (bDNA) molecules and new probe design to improve the amplification of marker chemical signals on the target DNA sequence without the need to amplify the target sequence itself (as shown in Figure 1). The working principle is as follows: each oligonucleotide probe group contains two types of synthetic probes, namely, capture extension probes (CEs) and labeled extension probes (LEs). Both CEs and LEs can bind to the target DNA sequence. First, MagPlex ™ Microspheres (magnetic beads) coupled capture probe captures the target DNA sequence through the common hybridization between CEs-capture probe and CEs-target DNA. Then, LES can combine with target DNA and preamplified probe at the same time. One preamplification probe contains 20 sites that bind to the amplification probe, and one amplification probe also contains 20 sites that bind to the labeled probe. Therefore, the target signal is finally amplified by 400 times. Finally, the biotin-labeled probe is combined with the phycoerythrin labeled streptavidin (SAPE), and the fluorescence intensity on the magnetic beads is measured by Luminex instrument such as MAGPIX. The fluorescence intensity is proportional to the number of DNA molecules present in the sample, and the level of cfDNA in the sample can be calculated. This method realizes the highly sensitive quantitative detection of cfDNA concentration in plasma samples, with the advantages of no extraction, no amplification, easy operation, short detection cycle, and suitable for clinical detection. By comparison, Canales and other scholars found that SuperbDNATM showed some advantages over PCR in detecting 244 common genes, such as smaller deviation; Eliminating the influence of errors caused by DNA extraction loss and amplification; Avoid cross contamination of samples; It is easy to realize automation and batch detection [15]. This technology provides necessary technical support for us to monitor the changes of cfDNA during tumor treatment.
Britain
2023-03-12
Bullet-proof and radiation-proof ultra-high polymer materials
Equipment manufacturing
Change the arrangement order of ultra-high polymer, add new elements, and improve the performance and function of ultra-high polymer materials. At the same time, combine the new ultra-high polymer materials with the structure of daily clothes and bags, so that they can be turned into concealed protective articles for daily use. By transforming the structure of clothing and luggage, it can be transformed quickly and its use scenarios can be greatly increased. It can not only deal with various civil emergencies, but also be used by special groups. Because of its extensive performance, it is also widely used in the battlefield. Main principle: change the arrangement order of the ultrahigh polymer, add new elements, improve the performance and function of the ultrahigh polymer material itself, and combine the new ultrahigh polymer material with the structure of daily clothes and bags, so that it can be turned into a concealed protective article for daily use. By transforming the structure of clothing and luggage, it can be transformed quickly and its use scenarios can be greatly increased. It can not only deal with various civil emergencies, but also be used by special groups. Because of its extensive performance, it is also widely used in the battlefield. Achievement form and key indicators: in the field of materials: the improved ultra-high polymer material can be used to prevent sharp weapons, blunt impact, bullet impact, shrapnel impact and radiation attack. Our materials: on our materials with an area of 25 * 30cm a year, we can defend against the impact of NIJ IIIA guns and the 12-meter dash of the sabre; Grenade shrapnel; Radiation and radiological attacks. Prevent users under 100 kg from drowning. Technical features and advantages: technical features: change the arrangement order of ultra-high polymers and add new elements. Material advantages: make it lighter, stronger and more widely used than traditional ultra-high polymer materials. Institutional advantages: daily clothing and bags can be quickly deformed, and traditional bulletproof clothing can be quickly worn to solve the problem of rapid emergency response. Comparison of relevant technologies at home and abroad and future trends: compared with our materials, such as 25 * 30cm, the foreign materials weigh about 0.2kg, the durability difference is about 2 years less than ours, the use scenarios are less (there is no possibility of drowning prevention, radiation prevention and blunt force prevention), the use scenarios (military police) and we can also use them for civilian or special purposes. Future trend: new materials are lighter on the original basis, have a wider range of applications, and can cope with more scenarios. They will be widely used in civil, military, aerospace.
United States
2023-03-12
Research and development project of 9Y-1450 round baler
Equipment manufacturing
1. Strong technical support. The company's technical partner, Belgomery Agricultural Machinery Factory, is one of the largest agricultural machinery manufacturers in the world. The company has strong technical strength and is at the world's leading level in the field of professional harvesting machinery. 2. Strong innovation ability. The company has 41 core technologies, including 7 invention patents, 32 utility model patents and 2 appearance patents. At present, all patent achievements have been implemented. 3. Strong R&D team. The company has 28 R&D personnel, accounting for 20% of the total number of employees. 4. Perfect R&D equipment. The enterprise has invested nearly ten million yuan in the purchase of equipment. At the same time, the enterprise is also continuously purchasing more advanced equipment according to the research and development content, providing equipment support for improving the enterprise's research and development level. 1. How to quickly and cleanly pick up the straw and then enter the baling chamber; 2. How to quickly compact and bundle the collected straw; 3. How to automatically bind the net after the bale reaches the specified size. Through the introduction of foreign advanced and mature technologies and talents, the following tasks have been accomplished: 1. Develop efficient pickup devices to realize the rapid pickup and transportation of straw; 2. Develop efficient binding device to realize rapid compaction and binding of straw; 3. Develop an automatic net binding device to realize the net binding after the bale forming; Develop an automatic control system to intelligently control the functions of automatic compaction and baling, net binding, and bale dropping of the straw bale. 1. The transformation of domestic agricultural planting structure from a dualistic structure to a ternary structure of "grain crops+cash crops+feed crops" will be accelerated, and grass baling is in the ascendant; 2. Driven by environmental protection policies, the demand for straw bundling is booming; In view of the serious situation of environmental pollution and haze, the state has continued to strengthen the treatment of straw burning, not only issued relevant policies, but also increased the punishment; 3. In recent years, with the improvement of farmers' living standards, the improvement of rural energy structure and the cost of straw collection, sorting and transportation, the comprehensive utilization of straw has lagged behind, especially in some major grain-producing areas, the phenomenon of farmers' burning straw in order to sow seeds during the agricultural season has become a social problem. How to rationally use corn straw and combine the promotion of comprehensive utilization of straw with agricultural efficiency and farmers' income
United States
2023-03-12
Implementation Measures for Talent Introduction of Shijiazhuang Railway University
Education/Training
The experimental equipment required for this project has been provided, the experimental conditions are sufficient, the financial guarantee is sufficient, and the experimental conditions are good. This research relies on the State Key Laboratory for Mechanical Behavior and System Safety of Traffic Engineering Structures jointly built by the Ministry and the Ministry of Transport, the Provincial Key Laboratory for Traffic Safety and Control in Hebei Province, Hiroshima University in Japan, Chungnam Research Institute in Korea, and the Driving Simulation Center of Korea Road Traffic Research Institute. It has a strong innovation ability including Yan Zhao scholars, winners of the National Natural Science Outstanding Youth Fund, and "Tugong experts" in Hebei Province Scientific research team with teamwork spirit. At the same time, South Korean cooperative laboratories, universities and researchers can provide advanced technology, operating experience and experimental guidance. The main experimental equipment includes the simulation pilot, VISSIM simulation system, Eyeso ED100H headworn eye tracker, brain wave tester, BIM modeling system, railway transportation simulation system, urban road traffic signal coordination and control system, hypermap geographic information system platform, etc., which can effectively serve the experimental design, experimental modeling, experimental development and data analysis of the project research. The technical means and analysis methods adopted in this project have been widely used in actual traffic planning and traffic problem solving, and have achieved good results, without technical problems. The main difficulty of the project is the current situation and data acquisition of the traffic network between Xiong'an New Area and the surrounding areas, which are specifically shown in the following three points: • Research on the layout system of the greenway traffic network system between Xiong'an New Area and the surrounding areas; the urban construction of Xiong'an New Area has a good planning scheme and advanced concept, and has a clear fault with the development of small and medium-sized cities in the surrounding areas. How to build the advanced urban greenway traffic network with the urban layout of the surrounding areas and determine the greenway traffic system within the area of Xiong'an New Area is a difficult point in the planning and layout research Research on the interactive development benefits of the greenway transportation network between Xiong'an New Area and surrounding areas; how to evaluate the benefits from the multi-dimensions of economic development, regional coordination, and public awareness is a research difficulty in the construction of the greenway transportation network and the connection between Xiong'an New Area and surrounding areas Data survey on the development status of the greenway in Xiong'an New Area Xiong'an New Area is at the primary stage of urban construction, and the rationality and functionality of the greenway traffic network planning and construction cannot be supported by data. Therefore, obtaining the basic data of the overall greenway traffic network in the region is one of the main difficulties of this study. ① Solution The project closely focuses on the construction of the greenway network connecting the inside and outside of Xiong'an New Area. The main solutions include four aspects. First, establish a project team with foreign intellectual expert teams to carry out international cooperation and academic discussions, and carry out exchanges and cooperation on project implementation, technical methods and other aspects. Second, through theoretical analysis and on-site traffic survey, determine the relevant data of the greenway traffic network in Xiong'an New Area, and form relevant data materials. Thirdly, carry out numerical modeling and simulation according to the survey. Based on the preliminary survey data, the mathematical model is established to establish a reasonable greenway traffic model, which is verified by simulation experiments. Fourth, strengthen industry-university-research cooperation, promote multi-disciplinary and multi-disciplinary intersection, and carry out sustainable research on greenway transportation network from a comprehensive perspective. ② The expected goal is that in the next three years, the research on greenway traffic network will be based on the urban construction of Xiong'an New Area and the integration of Beijing, Tianjin and Hebei, give full play to the discipline advantages and technical forces of Shijiazhuang Railway University and South Korea Chungnam Research Institute to carry out basic research such as theoretical analysis, traffic survey, numerical modeling, simulation simulation and so on, establish and improve the innovation system, and provide theoretical basis for the construction of greenway network in Xiong'an New Area. Carry out research on relevant policies, regulations and implementation standards for the greenway traffic network, establish laws, regulations and management systems suitable for the greenway traffic network in Xiong'an New Area, and generate good economic and social benefits. Based on this, the project team will strengthen the construction of first-class disciplines and student training, and strive to build a provincial and national first-class scientific research team with clear research direction, excellent scientific research ability and advanced management concept. During the construction period, we will make full use of the technical strength of Shijiazhuang Railway University and Chungnam Research Institute of Korea, focus on strengthening the construction of scientific research achievements and student training, rapidly improve the research level and ability, strive to publish 3-5 papers in core journals such as SCI, 2-4 state-authorized patents, train 3-5 postgraduate students, and participate in 10 academic exchanges and international conferences. The implementation measures for talent introduction of Shijiazhuang Railway University were put forward as a national development strategy in 2017, and the Outline of Hebei Xiong'an New Area Planning was put forward in 2018, which formulated the development objectives and planning direction of Xiong'an New Area. The Outline of Hebei Xiong'an New District Planning proposes the development goal of building a modern comprehensive transportation system, building a green and low-carbon city, and building a convenient, safe, green and intelligent transportation system. It is necessary to establish a cross-regional comprehensive greenway transportation network. Relying on the landscape design, the greenway is a traffic corridor integrating the road and the landscape. Greenway traffic is a green space corridor system that combines road traffic attributes with natural landscape and highlights the functions of slow traffic and tourism services. It has the characteristics of low investment, short cycle, small land occupation, low carbon and environmental protection, meets the development requirements of modern green cities, and is one of the effective measures to improve road conditions, improve infrastructure, promote economic growth, and meet the needs of people's spiritual and civilized life. The study of greenway in foreign countries began in the middle of the 19th century, and gradually developed to the present stage of greenway movement. From the initial park greenway construction to urban, regional and international greenway projects, a large number of special studies and academic conferences have been conducted. With the development of Internet technology, greenway traffic research has begun to develop in the direction of Internet and intelligence. South Korea, the United States and Germany have made remarkable achievements in the layout of greenway traffic network. South Korea has a small land area and a lack of natural resources. It provides a new development model for citizens to improve traffic conditions by establishing a greenway network to connect mountains, forests, parks, etc. The United States has built a greenway connecting important cities, parks and tourist attractions along the east coast, bringing in 16.6 billion dollars in tourism revenue and good economic and social benefits. The construction of the greenway in Ruhr District of Germany in the traditional industrial park has not only improved the quality of life of the residents, but also integrated the resources of land use, and defined the construction and development of the regional greenway through legislation. China's greenway construction has the characteristics of late start, low level of development, limited functional layout, weak regional connectivity and rapid development. Since the introduction of the concept of greenway transportation in the Pearl River Delta in 2009, by the end of 2018, China has built a total of 56000 kilometers of greenways, and urban greenways are becoming the development trend of urban green transportation travel. The Pearl River Delta greenway is the first regional greenway transportation network built, connecting the natural and cultural attractions in the surrounding area, undertaking the three major metropolitan areas, and driving the development of about 26 million people around. Greenway construction in other cities, such as Beijing, Chengdu, Wuhan and Changsha, has set up greenway facilities with urban landscape roads as the main body, focusing on serving urban residents. At present and in the future, the overall demand for transportation in our province is still strong, the development space continues to expand, the rigid constraints continue to strengthen, and the contradiction between people's growing spiritual needs and urban transportation development is increasingly prominent. Building a "people satisfied" green transportation network is not only to comply with the development of the times, but also to meet the urgent needs of the people.
Britain
2023-03-12
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