Research and development project of inhaled drugs through the lungs

The research direction is molecular nutrition, which is the core technology of transpulmonary drug delivery technology. The background of the project for transpulmonary inhalation drug technology is Dr. Liu Jinzhou, President of Natural Medicine Corporation of the United States, and the international transpulmonary drug delivery technology provided by the R&D team, which has a huge promoting effect on the overall pharmaceutical level of Shijiazhuang. Based on the need to apply transpulmonary drug delivery technology to achieve modernization and internationalization of traditional Chinese medicine, in order to promote the comprehensive development of the biopharmaceutical industry in Shijiazhuang, Establish a public service platform for lung inhalation technology, and complete clinical research on new drugs, especially lung delivery technology. Expected goal: After the completion of this platform, we will collaborate with Shijiazhuang pharmaceutical companies to develop various new inhaled drugs, providing technical support for local pharmaceutical companies to absorb a large number of new drugs. Within one year after the platform's inspection and operation, we will provide technical information for the approval of a generic inhaled drug for Shijiazhuang pharmaceutical companies to obtain a special high-level generic drug. We now have the necessary conditions (equipment/personnel/funds) to purchase V-type high-efficiency mixing machines, automatic particle packaging machines, and other equipment. Dr. Liu Jinzhou, Ph.D., Ph.D., postdoctoral fellow in molecular nutrition. Dr. Laura LiewelIyn, Ph.D., and Scott McCaig, Ph.D., have technical difficulties/main difficulties. Currently, one of our research directions is the design and transformation of enzymes. In this direction, the cooperative unit can predict the structure of the target enzyme based on the existing data and literature results, use professional technical tools, and calculate and analyze the key sites of the enzyme structure and function on this basis, such as analyzing the active site of the enzyme and the key sites that affect protein stability, analyzing the catalytic mechanism of the enzyme, and carry out rational or semi rational design based on our requirements, Assist us in developing a transformation plan ⑵ Provide necessary basic theoretical and technical training to our technical personnel to equip them with basic bioinformatics knowledge.